Tyrosols and derivatives
Medchemexpress LLC VX-702 50mg | 745833-23-2 | 50MG
VX-702 is a highly selective inhibitor of p38 MAPK 14-fold higher potency against the p38 versus p38 [1
Apexbio Technology LLC VX-702 479543-46-9; 745833-23-2 10mM (in 1mL DMSO)
VX-702 is a small-molecule inhibitor targeting p38 mitogen-activated protein kinase (MAPK) also known as MAPK14 It is designed to inhibit p38 MAPK thereby regulating cellular responses to cytokine signaling and various stressors VX-702 exerts its biological activity primarily through ATP-competitive inhibition In experimental models VX-702 demonstrates potent inhibition with reported IC50 values ranging from 4 to 20 nM Based on these pharmacological properties VX-702 holds research potential in the study of p38 MAPK-dependent pathways platelet storage lesions and renal excretion mechanisms
Medchemexpress LLC 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)pyridine-3-carboxamide | 745833-23-2 | MFCD11616590 | 99.7% | 404.32 g/mol | C19H12F4N4O2 | 1 ML
VX-702 is a selective small-molecule inhibitor of p38α mitogen-activated protein kinase (MAPK) used in research to probe p38α-mediated signaling and inflammatory pathways. It demonstrates higher potency for p38α than p38β and has been evaluated in preclinical and clinical studies for anti-inflammatory applications. Supplied for laboratory research use only.
- Selective p38α MAPK inhibitor with approximately 14-fold selectivity over p38β.
- Suitable for studying inflammatory signaling and cytokine regulation.
- Provided as a 10 mM solution in DMSO for ready-to-use applications.
- High purity (product page lists 99.69%), appropriate for biochemical assays.
- Molecular weight 404.32 g/mol and formula C19H12F4N4O2.
- Good solubility in DMSO (≥ 42 mg/mL) for convenient stock preparation.
- For research use only; not intended for human or veterinary use.
Medchemexpress LLC 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)pyridine-3-carboxamide | 745833-23-2 | MFCD11616590 | 99.7% | 404.32 g/mol | C19H12F4N4O2 | 100 MG
VX-702 is a small-molecule research inhibitor selective for the p38α isoform of mitogen-activated protein kinase (MAPK). It is used to probe MAPK signaling and inflammatory cytokine production in preclinical and cellular studies. The compound is supplied as a powder with high reported purity and documented potency against p38α.
![Medchemexpress LLC 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide | 745833-23-2 | MFCD11616590 | >98.0% | 404.32 | C19H12F4N4O2 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242623.png-250.jpg)
Medchemexpress LLC 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide | 745833-23-2 | MFCD11616590 | >98.0% | 404.32 | C19H12F4N4O2 | 200 MG
VX-702 is a research-grade small-molecule inhibitor selective for p38α mitogen-activated protein kinase (MAPK). It exhibits approximately 14-fold higher potency for p38α versus p38β and has demonstrated both in vitro and in vivo activity in preclinical inflammatory models. The compound is supplied as a high-purity material suitable for biochemical, cellular, and pharmacology studies.
- Selective p38α MAPK inhibition with approximately 14-fold selectivity versus p38β.
- Potent in vitro activity with reported IC50 values in the ~4-20 nM range.
- Reduces proinflammatory cytokine production (IL-6, IL-1β, TNFα) in dose-dependent studies.
- Documented in vivo pharmacokinetics, including a reported half-life of 16-20 hours.
- Supplied at high purity (>98%).
- Soluble in DMSO at ≥42 mg/mL for assay preparation.
- Intended for research use only.
Apexbio Technology LLC Verbascoside 61276-17-3 100mg
Verbascoside (CAS 61276-17-3) is a small-molecule inhibitor targeting protein kinase C (PKC) and the NF- B signaling pathway It is designed to modulate these pathways thereby regulating signal transduction and transcriptional activity in cellular responses Verbascoside exerts its biological activity primarily through the inhibition of PKC and suppression of NF- B DNA-binding activation In cell-based studies Verbascoside demonstrates inhibitory activity with an IC50 value of approximately 4 8 M in RANKL-treated RAW264 7 cells and bone marrow macrophages (BMMs) Based on these pharmacological properties Verbascoside holds research potential in the investigation of PKC/NF- B-mediated signaling osteoclastogenesis and related cell signaling mechanisms
Apexbio Technology LLC VX-702 479543-46-9; 745833-23-2 50mg
VX-702 is a small-molecule inhibitor targeting p38 mitogen-activated protein kinase (MAPK) also known as MAPK14 It is designed to inhibit p38 MAPK thereby regulating cellular responses to cytokine signaling and various stressors VX-702 exerts its biological activity primarily through ATP-competitive inhibition In experimental models VX-702 demonstrates potent inhibition with reported IC50 values ranging from 4 to 20 nM Based on these pharmacological properties VX-702 holds research potential in the study of p38 MAPK-dependent pathways platelet storage lesions and renal excretion mechanisms
Medchemexpress LLC Abt-702 dihydrochloride | 1188890-28-9 | 99.8% | 536.25 g/mol | C22H21BrCl2N6O | 100 MG
ABT-702 dihydrochloride is a potent, non-nucleoside adenosine kinase (AK) inhibitor (IC50 = 1.7 nM), supplied as the dihydrochloride salt for research use. It is used in biochemical and cellular studies to modulate adenosine kinase activity.
- Potent adenosine kinase inhibitor with IC50 = 1.7 nM.
- Dihydrochloride salt form for improved stability and solubility.
- Molecular formula C22H21BrCl2N6O; molecular weight 536.25 g/mol.
- Intended for research use in biochemical and cellular assays.
- Store sealed away from moisture; in solvent, -80°C (up to 6 months) or -20°C (up to 1 month).
Selleck Chemical LLC Verbascoside S5458-5mg
Verbascoside (Acteoside Kusaginin) a phenylpropanoid glycoside from lemon verbena has several biological properties such as anti-inflammatory antimicrobial antitumor and antioxidant
Selleck Chemical LLC VX-702
VX-702 is a highly selective inhibitor of p38 MAPK 14-fold higher potency against the p38 versus p38
eMolecules ChemScene / 246-Tribromophenyl methacrylate / 1g / 625603901 / CS-0179372 / 0.000 / 37721-71-4 / MFCD00078329 / 398.876 / C10H7Br3O2
ChemScene / 246-Tribromophenyl methacrylate / 1g / 625603901 / CS-0179372 / 0.000 / 37721-71-4 / MFCD00078329 / 398.876 / C10H7Br3O2